The First Program to Prevent and Reverse Cognitive Decline: Dale Bredesen MD

  • Michael
  • June 10, 2018
  • Comments Off on The First Program to Prevent and Reverse Cognitive Decline: Dale Bredesen MD

Introduction

  • ReCODE addresses the foundational causes of Alzheimer’s disease,
  • ReCODE is a protocol for improving brain function and explains how to optimize cognitive performance with biochemistry, sleep, exercise, stress reduction and diet
  • ReCODE stands for Reversal of Cognitive Decline.
  • This is a program custom-made to the individual based on the abnormal lab test values
  • It identifies 36 factors related to metabolism that have a significant influence on cognition
  • These are factors that traditional neurologists do not usually consider

Related articles

I posted a comprehensive guide for memory improvement. It talks about how the memory system works in the brain and certain techniques you can apply to increase memory. You really need to check this out!

The link is here: http://healingideas.org/comprehensive-memory-guide/

Also proper diet and reducing blood sugar is necessary to improve cognition. I have provided complementary information about the ketogenic diet here: http://healingideas.org/keto-diet-strategy/

Also nicotine has tremendous potential to help people with impaired cognitive abilities. Here’s the link to that article: http://healingideas.org/nicotine-effects-on-brain-function/

Infrared Light and Red Light has been proven to help with dementia and other cognition issues. Heres the link: http://healingideas.org/infrared-light-and-the-brain/

 

Alzheimer’s Disease is a Protective Mechanism from Three Specific Things

  • Inflammation
  • Deficiencies
  • Toxins

 

Functions of Amyloid Beta

  • Amyloid-beta is part of the inflammatory response and can function as an antimicrobial agent
  • It responds to inadequate levels of hormones, vitamins, nutrients, and other supportive (or trophic) factors by downsizing the more expendable synapses
  • It is also part of the protective response to toxin exposure

 

  • Amyloid is involved with inflammation in the brain

 

  • It has properties that destroy of prevent the growth of microorganisms

 

  • If certain variables are insufficient in the brain, amyloid beta reduces the amount of synapses connecting the neurons

 

  • When the brain is exposed to toxins, amyloid helps to protect the brain

 

 

Types of Alzheimer’s Disease

Type 1

  • “Inflammation” form of Alzheimer’s disease
  • This form of the disease is associated with one or two ApoE4 alleles
  • The ApoE4 gene is found in at least 25% of the U.S. population

 

Type 2

  • “Wasting” form of Alzheimer’s disease
  • This form of the disease is associated with one or two ApoE4 alleles
  • Lab results usually do not show any inflammation
  • Hormone levels are “off”
  • Synapses for the brain do not have supportive factors

 

Type 1.5

  • Mix of Type 1 and 2 forms of Alzheimer’s disease
  • There is increased inflammation and less supportive factors for the synapses
  • “glycotoxic” (sweet) form of Alzheimer’s disease
    • Blood sugar levels are much higher than normal
    • Insulin levels are much higher than normal

Type 3

  •  “toxic” form of Alzheimer’s disease
  • Created from exposure to toxins
  • Hormone levels are “off”
  • Zinc measures are below normal
  • Copper to zinc ratio is higher than normal
  • Signs of inflammation in the brain

 

Protocol for Improving Brain Function: Important Tests for Improving Cognitive Performance

Homocysteine

  • Lab tests for homocysteine are used to show inflammation
  • It can also be used to show a loss of support factors for the synapses
  • Blood vessels and the brained can be harmed by excess homocysteine
    • The hippocampus part of the brain wastes away faster, the higher the homocysteine values are above 6
  • Supporting nutrients to lower homocysteine include
    • Vitamin B6, B12, Folate and Betaine

 

Vitamins B6, B12 and Folate

  • Supporting nutrients to lower homocysteine levels

Cell Resistance to Insulin

 

  • It is imperative to control insulin levels and blood sugar levels
    • Both significantly increase the chance of getting Alzheimer’s disease
  • The body was not built to consume and handle more than 15 grams of dietary sugars during any given day
  • Insulin can act as a signal to prevent death of neurons
  • An enzyme that degrades insulin is also involved with degrading amyloid beta
    • If insulin it too high, this enzyme focus on degrading insulin and not amyloid plaques
  • Glucose can also latch onto proteins in the body
    • Proteins functions are either stopped or reduced

 

 

Inflammatory Responses

  • Multiple research papers have shown that there is evidence between inflammation in the body and Alzheimer’s disease
  • Key measures of inflammation
    • High Sensitivity C-Reactive Protein
    • Ratio of albumin to globulin
    • Ratio of Omega 6 to Omega 3
    • Interleukin-6 (IL-6) and Tumor Necrosis Factor Alpha (TNFa)
  • Multiple research papers have shown that there is evidence between inflammation in the body and Alzheimer’s disease

 

Vitamin D

  • Turns on genes that are essential for forming and preserving brain synapses
  • Vitamin D can provide a stimulus to genes so that the genes form and preserve the synapses in the brain

 

Hormones

  • Hormones are necessary to optimize cognitive function
  • The word hormone means “to impel or set in motion” in Greek
  • Thyroid Status
    • To improve cognitive function, it is important to optimize thyroid hormones
    • Lab results for Alzheimer’s patients often show that thyroid levels are “off”
  • Estrogen and Progesterone
    • Estrogen activates an enzyme that support synapses in the brain
    • There is also a connection between brain fog and memory issues with the percentage of estradiol to progesterone
  • Testosterone
    • Helps to sustain neurons
  • Cortisol
    • If cortisol levels get too high, it can harm neurons
    • Research has shown that if a significant amount of cortisol is reduced in a short amount of time it can damage the neurons in the hippocampus
  • Pregnenolone
    • Stress hormones and sex hormones come from pregnenolone
    • Pregnenolone helps with memory functions
    • It also helps to protect the brain
  • DHEA
    • DHEA is a neurosteroid
    • It supports the way the body responds to stress

 

Metals

  • Scientific research has associated dementia with
    • Too much copper
    • Too little zinc
  • When zinc levels are low it increases the body’s sensitivity to toxins
  • Zinc is involved with creating insulin , storing insulin and the release of insulin
  • When zinc is lacking it influences the signaling of insulin
  • Low levels of zinc can cause autoantibodies to rise
    • This process changes the neurotransmitter signaling and hormone signaling
  • Magnesium
  • Magnesium is necessary for optimal brain cell function
    • Cognition improves with magnesium threonate.
    • Magnesium threonate is the best form of magnesium to increase magnesium levels in the brain
  • Selenium and Glutathione
    • Selenium and glutathione are antioxidants
    • Glutathione helps to prevent inflammation and toxin buildup
    • Selenium helps to “restart” glutathione
    • Research has shown a relationship between low selenium levels and cognitive decline
  • The body responds to mercury by creating amyloid-beta plaques and neurofibrillary tangles
  • Research has also shown that cognitive decline can be a result of Arsenic, cadmium and lead

 

Sleep

  • It is believed that sleep cleans the brain from cellular by-products
  • Cellular autophagy happens during sleep. This is like recycling for the cells

 

Cholesterol

  • Cell membranes are made of cholesterol
  • Research has shown that brain shrinkage can happen when cholesterol levels are lowered below 150

 

Vitamin E

  • Safeguards the membranes of the cells
  • Research has shown that Vitamin E helps to reduce cognitive decline in Alzheimer’s patients

 

Vitamin B1

  • Thiamine is utilized by the brain for memory processes
  • Certain foods have enzymes that damage thiamin

 

Gut Permeability

  • Zonulin is a factor in gut permeability
  • Leaky gut can cause inflammation throughout the body
  • This inflammation is a result of an immune response
  • Autoimmune conditions can be a by-product of this immune response
  • There is a leaky gut test available
    • It tests for two different sugars in the blood stream
      • One type of sugar, called mannitol normally reaches the blood stream
      • While the other sugar is not supposed to reach the blood, this sugar is called lactulose
      • If the gut has larger holes than normal, the lactulose will go through

 

Blood Brain Barrier Permeability

  • The blood brain barrier separates the blood flowing in the body from the brain tissue
  • It is created from cells that line the interior surface of the blood vessels
  • If the blood brain barrier is permeable it can cause pathogens to enter
    • People with Alzheimer’s disease have had gingivitis bacteria and fungal signatures in their brains
      • One study showed that some people with a certain type of fungal signature in their brains were less likely to get Alzheimer’s.
  • Research has also shown that the herpes simplex virus lives for years in the nerve cells connecting the brain
  • After someone is infected with syphilis bacteria, the pathogen can survive in the body for decades
    • Syphilis has been shown by research to be a cause of dementia

 

  • Pathogens and microscopic organisms can access the brain though many different routes.
    • Microorganisms can reach the brain though the nose and sinus passages
    • They can access the brain through the eyes
    • And also though the gut endothelial cells

 

Gluten Intolerance

  • Gluten can influence the way that zonulin controls the gut barrier

 

Autoantibodies

  • The body can confuse proteins in the brain with a foreign substance. This results in auto antibodies to damaging the brain

 

Toxins

  • Research has shown that mold toxins can cause cognitive problems and even Alzheimer’s disease
  • Mycotoxins can lead to chronic inflammatory response syndrome
  • Statins can cause problems with synapse processes

 

Mitochondria Processes

  • Mitochondria creates ATP from combining food and oxygen.
    • ATP is the energy that all cells use
  • Are descendants of bacteria that invaded our cells over a billion years ago taking up long term residence
  • There is a theory that mitochondria were once bacteria. They look a lot like bacteria. And the mitochondria invaded our cells and treated the cells like a Petri dish. Then learned to coevolve with us
  • The Greek word for mitochondria is “little granular thread”

BMI

  • The  Body mass index range should be between 18 and 25 to improve brain function

 

Computer Programs to Test Cognitive Performance

  • CNS Vital Signs
  • BrainHQ
  • Dakim
  • Lumosity
  • Cogstate
  • Posit science

 

Protocol For Improving Brain Function: Diet

  • Ketogenic diet called the Ketoflex 12/3
  • The flex in ketoflex refers to a flexitarian diet
    • This means consuming a lot of nonstarchy vegetables
  • The 12/3 part refers to fasting times
    • “12” refers to 12 hours between dinner and the next meal
  • “3” refers to the minimum amount of time between the end of dinner and bedtime
  • Most of the foods you consume should have a glycemic index of 35 of lower

 

 

Protocol For Improving Brain Function: Supplements

  • Acetyl L Carnitine
  • B12/Folate Combination
  • Citicoline
  • Niotinamide Riboside
  • Omega 3
  • Panthothenic acid
  • PQQ
  • Resveratrol
  • Ubiquinol
  • Vitamin B1
  • Vitamin C
  • Vitamin D
  • Vitamin E
  • Vitamin K2
  • Whole coffee fruit extract

 

These Supplements Support Synapse Connections

  • Ashwagandha Bacopa
  • Gotu Kola
  • Guggul
  • Lions Mane
  • Rhodiola
  • Skull cap
  • Triphala